Table 2. Effects of Muraru peel ethanol extract on blood parameters in the acute toxicity study.
Parameters |
Units |
500mg/kg |
1000mg/kg |
2000mg/kg |
Control |
p-value |
RBC |
106 /μL |
7.32± 0.19 |
7.23± 0.12 |
7.72± 0.17 |
7.93± 0.04 |
0.1387 |
HB |
g/dL |
13.15±0.32 |
13.40± 0.17 |
14.10± 0.25 |
13.68± 0.09 |
0.0570 |
HCT |
% |
37.35± 0.55 |
39.85± 2.26 |
38.03± 1.11 |
38.80± 0.52 |
0.5887 |
MCV |
fL |
55.85± 0.79 |
54.15± 0.39 |
54.45± 1.14 |
54.28± 1.16 |
0.5541 |
MCH |
Pg |
20.20± 0.76 |
19.15± 0.24 |
19.85± 0.52 |
18.68± 0.06 |
0.1587 |
MCHC |
g/dL |
34.83± 0.46 |
35.45± 0.35 |
37.33± 1.12 |
34.68± 0.45 |
0.0565 |
PLT |
103/μL |
781± 4.42 |
796.50± 9.08 |
804.75± 9.66 |
808.25± 4.35 |
0.0889 |
MPV |
fL |
6.90± 0.27 |
7± 0.25 |
6.73± 0.11 |
6.75± 0.12 |
0.7471 |
WBC |
103/μL |
6.28± 0.11 |
6.31± 0.12 |
6.22± 0.11 |
6.55± 0.06 |
0.8813 |
NEU |
103/μL |
0.715± 0.02 |
0.75± 0.08 |
0.88± 0.06 |
0.89± 0.03 |
0.0595 |
LYM |
103/μL |
3.72± 0.20 |
3.87± 0.11 |
3.55± 0.18 |
4.06± 0.07 |
0.1541 |
MON |
103/μL |
0.01± 0.00 |
0.03± 0.01 |
0.02± 0.0 |
0.02± 0.0 |
0.3162 |
EOS |
103/μL |
0.02± 0.01 |
0.01± 0 |
0.01± 0.00 |
0.02± 0.01 |
0.2030 |
NEU % |
% |
11.42± 0.42 |
11.88± 1.03 |
14.26± 0.86 |
13.64± 0.48 |
0.0542 |
LYM % |
% |
59.31± 3.61 |
61.43± 1.85 |
57.09± 3.43 |
62± 0.68 |
0.5721 |
MON % |
% |
0.2± 0.04 |
0.40± 0.1 |
0.36± 0.04 |
0.34+-0.10 |
0.3274 |
AST |
μ/L |
113.50± 14.34 |
117.25± 17.38 |
119.38± 18.94 |
114.95± 13.84 |
0.9943 |
ALT |
μ/L |
56.65± 5.68 |
55.40± 5.19 |
62.83± 2.32 |
64.48± 2.91 |
0.3871 |
Creatinine |
mg/dL |
0.49± 0.03 |
0.50± 0.04 |
0.54± 0.03 |
0.50± 0.04 |
0.8314 |
Urea |
mg/dL |
50.65± 3.25 |
50.68± 0.77 |
58.15± 9.44 |
47.20± 3.44 |
|
RBC: Total red blood cell count; HB: hemoglobin; HCT: Hematocrit; MCV: Mean corpuscular volume; MCH: Mean corpuscular hemoglobin; MCHC: Mean corpuscular hemoglobin concentration; PLT: Platelet count; MPV: Mean platelet volume; WBC: Total white blood cell count; NEU: Neutrophils; LYM: Lymphocytes; MON: Monocytes; EOS: Eosin; %: Percentage. All values are expressed as a mean ± SEM (n = 3).